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Qué (quién) es myotonic reaction - definición
![40-year-old with myotonic dystrophy who presented with muscle wasting, bilateral cataracts, and complete [[heart block]]](https://commons.wikimedia.org/wiki/Special:FilePath/Myotonic dystrophy patient.JPG?width=200 "40-year-old with myotonic dystrophy who presented with muscle wasting, bilateral cataracts, and complete [[heart block]]")
![Heathcock]]'s synthesis of dihydroprotodaphniphylline features a highly efficient cascade involving two aldehyde/amine condensations, a Prins-like cyclization, and a 1,5-hydride transfer to afford a pentacyclic structure from an acyclic starting material.](https://commons.wikimedia.org/wiki/Special:FilePath/Dihydroprotodaphniphylline synthesis.png?width=200 "Heathcock]]'s synthesis of dihydroprotodaphniphylline features a highly efficient cascade involving two aldehyde/amine condensations, a Prins-like cyclization, and a 1,5-hydride transfer to afford a pentacyclic structure from an acyclic starting material.")
!['''Scheme 11.''' Pericyclic sequence for the synthesis of [2,2]paracyclophanes](https://commons.wikimedia.org/wiki/Special:FilePath/Scheme 11 - peri - pcyclophane.svg?width=200 "'''Scheme 11.''' Pericyclic sequence for the synthesis of [2,2]paracyclophanes")
!['''Scheme 14.''' Gold-catalyzed
formal intramolecular [4+2] cycloaddition of 1,6-enynes](https://commons.wikimedia.org/wiki/Special:FilePath/Scheme 14 - metal - gold enyne.svg?width=200 "'''Scheme 14.''' Gold-catalyzed
formal intramolecular [4+2] cycloaddition of 1,6-enynes")
!['''Scheme 15.''' Proposed cascade process in the formal intramolecular [4+2] cycloaddition of 1,6-enynes](https://commons.wikimedia.org/wiki/Special:FilePath/Scheme 15 - metal - gold enyne mech.svg?width=200 "'''Scheme 15.''' Proposed cascade process in the formal intramolecular [4+2] cycloaddition of 1,6-enynes")
Wikipedia
Myotonia is a symptom of a small handful of certain neuromuscular disorders characterized by delayed relaxation (prolonged contraction) of the skeletal muscles after voluntary contraction or electrical stimulation.
Myotonia is the defining symptom of many channelopathies such as myotonia congenita, paramyotonia congenita and myotonic dystrophy.
Generally, repeated contraction of the muscle can alleviate the myotonia and relax the muscles thus improving the condition, however, this is not the case in paramyotonia congenita. This phenomenon is known as the "warm-up" reflex and is not to be confused with warming up before exercise, though they may appear similar. Individuals with the disorder may have trouble releasing their grip on objects or may have difficulty rising from a sitting position and a stiff, awkward gait.
Myotonia can affect all muscle groups; however, the pattern of affected muscles can vary depending on the specific disorder involved.
People with disorders involving myotonia can have life-threatening reactions to certain anaesthetics called anaesthesia-induced rhabdomyolysis.
